study/01
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PubMed listing
Title page of the 2020 clinical study on PubMed. Use when introducing the evidence.
Welcome · how this library works
Pick what fits you. Send us your scripts. We will refine together.
This is the complete idea library for MIOME IB-ONE clinician-recorded video ads. Every concept is built to feel like a calm, credible mini-consult, not an influencer-style ad, not a hard sell. The goal is to sound like you are explaining something to a patient you respect.
The MIOME target audience is women aged 40 to 80 in the US who deal with constipation. The 47 concepts below are built around the many ways she might recognize herself: women who have tried everything, women whose digestion changed in perimenopause, GLP-1 users, caregivers, label-skeptics, women whose constipation traces back to a supplement change - and more.
Every concept builds naturally into the same two key messages from the 2020 clinical study, with study screenshots:
- Adults with constipation went from around 1 to nearly 6 bowel movements per week after 4 weeks of daily use.
- 0% to 98% of participants achieved normal stool consistency over the same 4 weeks.
The strain that delivers these results is Bacillus coagulans Unique IS-2 - and that's the exact strain IB-ONE is exclusively formulated with, at the same 2 billion CFU dose used in the clinical study.
The partnership process
How the MIOME content process works
A step-by-step walkthrough, grouped into four stages. Most MIOME content actually goes live from MIOME's own ad accounts - so a few steps near the end are only relevant if you are also posting on your own wall.
Optional
If you haven't already, set up your affiliate link
If you'd like a personal discount code and affiliate link to share with your audience, register with our affiliate platform: af.uppromote.com/miome/register.
Stage 1 · Before filming
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01
Pick your concepts
Browse the 47 ideas below. Pick the angles that feel most natural for you and your audience. Filter by topic if it helps. Feel free to adapt them, mix and match, or come up with something completely your own - these are here to spark ideas, not to box you in.
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02
Send us your hooks and script
For each video, send us a written short draft script along with 2 alternate hook options for filming. Ideally in a shared Google Doc so we can leave comments and tweak the wording inline together. Feel free to write in your voice - we'll shape it from there if anything needs adjusting.
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03
We review, approve, and send the partnership ad request
We review for accuracy, claim wording, compliance, and ad strength. You'll typically hear back within 48 hours. Up to 2 revision rounds available, usually just 1. At this stage we'll also send a Partnership Ad request from our end - approving it lets us run the content as a paid ad. (It will not appear on your own feed unless you also choose to post the Reel, which is the optional stage further down.)
Need more product on hand? If you'd like extra IB-ONE or IB-PRO boxes, just email us and we'll send some out.
Stage 2 · Filming
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Film the video
If you are doing multiple videos, ideally film one video at a time so we can give you feedback before you move on to the next - it usually makes the second and third videos stronger than batching them all in one session. If you do film more than one in a single session, try to vary the setting or styling between them - we've seen variation move performance.
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Film 2 additional clean hook variants
The hook is the opening sentence of the video - the first thing the viewer hears. Record each additional hook as its own clean 10 to 15 second clip, no text overlays, no title card, no image overlays. Lets us test different hooks against the same body of the video.
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Capture B-roll (optional)
Only if it makes sense and fits naturally - if the video already flows well as a talking-head piece, don't shoehorn B-roll in. When it does fit, the goal is "a moment in your day," not a polished hero shot - product on the kitchen bench while you talk, a quick clip of taking the capsule, the blister pack in your toiletry bag. The risk of overdoing B-roll is that the video starts feeling like an ad rather than a real consult, which is exactly what we don't want. Use your judgment.
Stage 3 · After filming
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Send the draft edit
Send us:
- The edited video, with everything already cut in: on-screen text overlays (your subtitle-style text), the study screenshots, your optional Reel cover, and any optional B-roll cuts.
- Your draft Instagram caption copy - the text that will sit underneath the post.
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Make revisions (if needed)
Once you send the draft edit, we'll get back to you with feedback if anything needs adjusting. The spoken script and hooks were already approved at step 03 - revisions at this stage are usually around things that emerge in the edit itself: on-screen text overlays (subtitles) that introduce wording we hadn't seen, an image overlay that needs swapping, hook clip choice once we see it cut together, or CTA placement/pacing.
Stage 4 · Wrap up
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Send final assets
Within 48 hours of approval (or of posting, if you're posting too), share a folder with 3 files:
- Final edited video - same one we approved, with on-screen text overlays, study screenshots, optional Reel cover, and any B-roll already cut in.
- Clean version - the same video with everything removed. Just you on camera with the original audio. No on-screen text overlays, no study screenshots, no B-roll cuts, no Reel cover. We use this clean version to produce any variations of the ad on our end.
- 2x hook clips, clean - no overlays, no title cards.
Stage 5 · Optional · if you're posting on your own account
Most MIOME content goes live from MIOME's own ad accounts. This stage only applies if your agreement also has you posting the Reel on your own wall.
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Post the Reel
Post only after final approval. Tag @miome.health, use the approved caption. Try not to post another Reel the same day.
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Set up ManyChat (optional)
If you'd like to add it: when a viewer comments a trigger word like "MIOME" or "constipation" on your post, ManyChat sends them an automatic DM with your affiliate link and discount code. The advantage: instead of telling viewers to "click the link in my bio," you turn every interested commenter into a direct DM with the exact link that earns you the commission. Setup walkthrough here: help.manychat.com / Instagram setup.
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Use approved FAQ replies in comments
If followers ask the usual questions on your post, paste from the Influencer FAQ section near the bottom of this page. For anything else, MIOME's full help center has the most common questions: miome.gorgias.help/en-US.
The full library
All 47 concepts. Filter, search, expand.
Each card opens to its three hook variants (click any hook to copy), talking points, the IB-ONE bridge line, visual cues, three CTA options, the evidence assets to overlay, and a compliance caution.
47 of 47 ideas
No ideas match those filters. Try clearing the search.
Claim guardrails
The language that keeps every ad on-spec
A note on naming: "IB-ONE" and "Bacillus coagulans Unique IS-2" are interchangeable in any of these concepts - you don't have to mention IB-ONE in every video. Some of our strongest ads talk about the strain by name and barely reference the product. Pick whichever fits your delivery.
Always include
Unless there's a clear exception, the three below should appear in every ad. Attribute both stats to the strain and to the 2020 clinical study on the strain, not to IB-ONE the product, with the matching study screenshot on screen at that moment. Both screenshots live in the asset gallery below.
- The strain. Bacillus coagulans Unique IS-2.
- Frequency. In the 2020 clinical study on this strain, adults with constipation went from around 1 to nearly 6 bowel movements per week after 4 weeks of daily use.
- Consistency. In the same 2020 clinical study, 0% to 98% of participants achieved normal stool consistency after 4 weeks.
Strengthen the case where it fits
Reach for these when the concept calls for more credibility. None of them are required.
- Studied dose. 2 billion CFU per capsule, one capsule a day - the same dose used in the clinical study.
- 8 week satisfaction program. The 2020 clinical study on the strain ran for 4 weeks - MIOME's generous satisfaction program gives you twice that window, so there's a real runway to see whether it's working. As with any probiotic, there are responders and non-responders, and this program is the practical answer to that. It removes the risk for the viewer (and the patient, when you're recommending it in practice): full refund, no questions asked.
- AEProbio 2025 Clinical Guide. The Clinical Guide to Probiotic Products Available in USA, published by the Alliance for Education on Probiotics (AEProbio). It's a clinician-facing reference used by US healthcare providers to look up evidence-graded probiotics by indication. IB-ONE is listed in the 2025 edition (page 2) with specific indications for constipation. Useful when you want third-party clinical credibility beyond the strain's own study data.
Phrases that stay on-spec
Lean on these where they fit naturally - they're the wordings that hold up best to compliance review.
- "Clinically studied" (never just "studied")
- "Clinical studies" (never "clinical trials")
- "Clinically studied in adults with constipation"
- "Supports normal bowel movements"
- "Supports stool consistency"
- "The strain matters"
- "Think in weeks, not days"
- "Discomfort" (never "painful")
Words/phrases to steer away from
These either create regulatory headaches or break trust with the audience. Easy to swap out once you know they're on the list.
- Treats / cures / prevents / fixes constipation
- Guaranteed results / works for everyone
- "Functional constipation" (just say "constipation")
- Any specific medical condition: IBS, SIBO, colitis, chronic constipation
- "Pain" / "painful" (use "discomfort" instead)
- Anything that reads like an FDA disease claim (heals, miracle, detox, etc.)
- Prefer not to use "motility"
An example shape, not a script
One way a 60-second ad might flow
Below is just an example of how a typical ad might break down into different sections, beat by beat. Plenty of great ads skip beats, reorder them, or do their own thing entirely - use it however it's useful to you. The image suggestions in the right column point at the asset gallery further down.
The opening
The strongest openings name the specific frustration the viewer is feeling in the first few seconds. Constipation usually lands in the first 1 to 2 lines. Some openings work mid-sentence on a stat instead. (See the hook variants on each concept card for examples.)
Credential
A single line like 'as a dietitian who works with a lot of constipated patients', 'as an IBS dietitian', or 'as a board-certified gastroenterologist who sees this every day'. Drop it in naturally - many of our top-performing videos have the credential a few seconds in rather than as the opening line.
Identify the persona
Name the specific viewer this video is for - the patient you're speaking to. The woman who tried fiber and it didn't help, the woman whose gut changed after 50, the woman dependent on a daily laxative, the woman who just started a GLP-1, etc. This is where the concept's angle lives.
The strain
Naming Bacillus coagulans Unique IS-2 is often part of every ad. Usually paired with a short reason most probiotics aren't built for constipation.
Frequency stat
~1 to ~6 bowel movements per week after 4 weeks of daily use. Attributed to the strain, with the chart on camera.
The product (optional)
Holding the IB-ONE box on camera, the 2 billion CFU dose, one capsule daily. Some of our strongest ads have done well without ever showing the product, just talking about the strain.
8 week satisfaction program
Often lands well as the closing reassurance. The 2020 clinical study ran for 4 weeks - MIOME's generous satisfaction program gives you twice that window. Responders and non-responders exist with any probiotic, so this is the practical answer. Full refund, no questions asked.
CTA
Meta ads: 'Click Shop Now for 20% off.' Organic: 'Comment MIOME for 20% off' or discount code.
Visuals to drop into your video
Visual assets
Every image listed below is bundled with this library. Click any thumb to open it full-size. Click any image thumbnail to open the full-size file, or use the per-file download buttons.
Study screenshots (9)
study/02
Download
1 to 6 bowel movements per week chart
The hero line chart from the 2020 clinical study: spontaneous bowel movements rose from ~1 to ~6 per week by week 4 (a 6.6x increase). Drop in when the 1 to 6 stat is said on camera.
study/03
Download
98% normal stool consistency table
Table 2 from the 2020 clinical study: 0% of probiotic-arm adults had normal stool consistency at baseline; 24% at day 15; 98% at end of study (week 4). Drop in when the 98% stat is said.
study/04
Download
PubMed listing (landscape)
Landscape-format PubMed title screenshot from the 2020 clinical study. Optional substitute for 01.
study/05
Download
Abdominal discomfort chart
CSS abdominal pain score from the 2020 clinical study. Mean score dropped from 0.94 at day 15 to 0.38 by week 4 (-60%), p=0.002.
study/06
Download
SBMs per week bar chart
Spontaneous bowel movements per week (bar version): ~1 to ~6 per week by week 4 in the probiotic arm, a 6.6x increase. Alternative to the study/02 line chart.
study/07
Download
Bristol stool consistency bars
Bristol stool form score by week from the 2020 clinical study. Mean score moved up to 3.02 by week 4 (p=0.021), with 98% of probiotic-arm adults reaching normal stool consistency.
study/08
Download
Incomplete-emptying chart
CSS 'feeling of incomplete evacuation' score from the 2020 study. Mean score dropped from 1.32 at day 15 to 0.88 by week 4 (-33%), p=0.034.
study/09
Download
100 people study zoom
Zoomed paragraph from the 2020 clinical study: 100 adults with constipation, ages 18-65, 2 billion CFU Unique IS-2 daily for 4 weeks.
IB-ONE product images (5)
product/ib-one-front
Download
IB-ONE front of box
Clean no-background render of IB-ONE. Default product hero - lighter and less ad-feeling than the full lifestyle shot.
product/ib-one-blister
Download
IB-ONE front with blister
Front of box with a blister pack visible.
product/ib-one-inuse
Download
IB-ONE in use
Lifestyle in-use shot.
product/ib-one-nobg
Download
IB-ONE no background
Cutout for clean compositing over study screenshots.
product/ib-one-facts
Download
IB-ONE supplement panel
The supplement-facts panel: 2 billion CFU of Unique IS-2.
IB-PRO product images (4)
product/ib-pro-front
Download
IB-PRO front of box
IB-PRO box front.
product/ib-pro-blister
Download
IB-PRO front with blister
IB-PRO box with blister pack visible.
product/ib-pro-facts
Download
IB-PRO supplement panel
IB-PRO supplement facts. Unique IS-2 plus Lactospore.
product/duo
Download
IB-ONE + IB-PRO together
Side-by-side product shot.
Comparison labels (2)
comparison/cfu-blend
Download
Generic 50B CFU multi-strain panel
Anonymous reference - we don't name brands. Use as a generic example of the 'proprietary blend' style with no per-strain dose.
comparison/gummy
Download
Probiotic gummy panel
Anonymous reference - we don't name brands. Use as a generic gummy probiotic panel: FOS, sugar alcohols, low CFU.
After filming · the caption insert
An example caption insert
A short block you can drop into the middle of any caption to save time. Write your own opening line and your own hashtags around it. The block itself is entirely optional - it's just here as a starting point if you'd like one.
Example insert
The strain inside MIOME's IB-ONE has been clinically studied for constipation: 📊 Adults went from ~1 to ~6 bowel movements per week in 4 weeks ✨ 98% achieved normal stool consistency MIOME's IB-ONE contains this exact strain at the clinically studied dose, and they stand behind it with an 8 week satisfaction program. If it doesn't work for you, full refund, no questions asked 💛 ✅ Click 'Shop Now' above to save 20%, or use code [YOUR CODE] at checkout
Suggested
- Open with constipation in the first 1 to 2 lines
- MIOME always written ALL CAPS
- Attribute clinical claims to the strain, not the product
- Numerals only (4 weeks, 98%)
- US spelling (fiber, color, behavior)
- Lean on the wordings from "Phrases that stay on-spec" above
Do not
- Name conditions other than constipation (IBS, SIBO, colitis, chronic constipation)
- Use #ibs / #ibsc / #sibo
- Treats / cures / prevents / fixes constipation
- Guaranteed results / works for everyone
- "Pain" / "painful" (use "discomfort")
- "Functional constipation" (just say "constipation")
- Anything that reads like an FDA disease claim (heals, miracle, detox, etc.)
- Prefer not to use "motility"
After posting · replies for the comments
Influencer FAQ - copy-paste replies
When followers ask the usual questions in the comments or DMs, paste from here. The replies are written in your voice, stay inside the claim guardrails, and lean on the 8 week satisfaction program where it helps. Anything unusual or medical, forward it to MIOME instead of answering.
Everyone's gut is a bit different so timing varies, but many people start noticing benefits after around 2 weeks of taking MIOME daily. From there it often gets better with consistency, and the best results usually come from taking it every day and giving your gut a few weeks to settle into a new rhythm. MIOME stands behind it with an 8 week satisfaction program - the 2020 clinical study on the strain ran for 4 weeks, so the program gives you twice that window. You can try it properly, and if it does not work for you, full refund, no questions asked. More info at miome.health/satisfaction.
Probiotics can take time and they don't work the same for everyone. Many people notice changes around weeks 3 to 4, with benefits sometimes building through weeks 4 to 8. In the 2020 clinical study on the strain inside IB-ONE, adults went from around 1 to nearly 6 bowel movements per week after 4 weeks of daily use. That said, MIOME does not want anyone stuck with something that is not working. Their 8 week satisfaction program means you can try it properly and request a full refund if it does not work for you. More info at miome.health/satisfaction.
Yes. MIOME's probiotic strains are shelf-stable and you can take them with or without food. I would focus on taking it consistently each day.
MIOME keeps their full FAQ up to date here: miome.gorgias.help/en-US. Anything specific to your health, it is best to chat with your healthcare professional.
Clinical evidence library · For clinician education
Three clinical studies on Bacillus coagulans Unique IS-2
Here are the three clinical studies on the strain inside IB-ONE. One of them can be used in MIOME video ads, captions, hooks, and any public-facing creative: the 2020 constipation study. The other two are in IBS and stay clinic-side - they're useful to know in patient conversations, but IBS is a medical condition and we don't reference it in MIOME creative. There's a much wider literature on Bacillus coagulans probiotics; these are the studies that map most directly to the strain in IB-ONE, with source PDFs attached.
The strain inside IB-ONE - Bacillus coagulans Unique IS-2 (MTCC 5260) - has three randomized, double-blind, placebo-controlled clinical trials behind it: one in adults with constipation, and two in IBS (one in adults, one in children). Each is summarized below in its own dedicated section.
Use in MIOME ads & clinic
1 · Constipation
Unique IS-2 in constipation - the foundation study behind everything we say about IB-ONE
This is the study every constipation stat in MIOME creative comes from. The 98% normal stool consistency number, the bowel-movement frequency, the reduction in abdominal discomfort - all of it traces back here. Worth re-reading whenever you script a hook.
Adults · 18 to 65 years · Constipation
Madempudi et al. 2020
- 98% achieved normal stool consistency by week 4. This is the figure that anchors our packaging and most of our ad creative.
- Spontaneous bowel movements rose from ~1 to ~6 per week by week 4, p<0.001 at weeks 3 and 4.
- Reduced abdominal discomfort. CSS abdominal pain score dropped from 2.2 at baseline to 0.38 at week 4, p=0.002.
- Reduced discomfort during evacuation. CSS difficulty-of-evacuation score dropped to 0.66 by week 4, p=0.006.
- Reduced feeling of incomplete evacuation. CSS score dropped to 0.88, p=0.034.
- Improved stool consistency on Bristol scale. Mean score rose to 3.02 by week 4, p=0.021.
- Safety. No adverse events in the probiotic group.
Clinic only - not for ads
2 · IBS (Unique IS-2)
Unique IS-2 in IBS - exceptional data, strictly for the clinic
Two randomized, double-blind, placebo-controlled trials on Unique IS-2 - one in adults, one in children. Both used 2 billion CFU daily for 8 weeks. The results are unusually strong for a probiotic in IBS. Use this in your own clinic, with patients. Do not put it in a MIOME ad.
Adults · 18 to 60 years
Madempudi et al. 2019
- Pain reduction. Baseline pain score dropped from 8.2 to 3.4 at week 8, p<0.001.
- Pain responders. 84.9% hit the ≥50% pain-reduction threshold at week 8; 90.6% by week 10. The ≥50% bar is stricter than the FDA ≥30% bar used in IBS drug trials.
- Bowel movements. Mean CSBM score rose from 2.5 to 4.0 per week; 79.3% became CSBM responders.
- Stool consistency. 65% achieved normal stool consistency by week 6.
- Patient Global Assessment. 18.9% reported complete relief and 64.2% reported considerable relief.
- Total IBS symptom severity. Mean score dropped from 26.4 to 10.6 - a 60% improvement.
- Safety. No adverse events.
Children · 4 to 12 years
Sudha et al. 2018
- Pain responders. 93.1% hit the ≥50% pain-reduction threshold at week 8.
- Eight symptom domains all improved significantly. Abdominal discomfort, bloating, urgency, incomplete evacuation, straining, passage of gas, bowel habit satisfaction, overall IBS assessment - all p<0.0001.
- Stool consistency. By week 6, around half of children in the probiotic arm had returned to normal stool consistency.
- Subject's Global Assessment of Relief. Total score dropped from 13.1 to 3.5. Significant reduction in family-life impact too.
- Safety. No treatment-related adverse events. No relapse two weeks after stopping the probiotic.
IB-ONE is also listed in the 2025 AEProbio Clinical Guide to Probiotic Products (Available in the USA) on page 2, with specific indications for both IBS and constipation. AEProbio is the clinician-facing reference US healthcare providers use to look up evidence-graded probiotics by indication.
How to use this in practice
In MIOME video ads: the constipation data is what you anchor to. The 2020 constipation study is the lead story - the 98% normal stool consistency number, the ~1 to ~6 bowel movements per week, the reductions in abdominal discomfort - all public-claim-safe and all traceable back to this single peer-reviewed paper.
Bonus depth in your own clinic: the two IBS studies give you the deepest clinical context. Unique IS-2 has unusually strong, replicated, peer-reviewed data in IBS across both adults and children. That data is yours to use in patient conversations - it just doesn't appear in MIOME ads.